Intelectin-1/ITLN1 蛋白, Human (N-His, C-myc)

Intelectin-1/ITLN1 is a lectin with specific affinity for microbial carbohydrate chains and recognizes β-linked D-galactofuranosose, D-glycerolphosphate modified glycans, D-glycerol-D-talo-oct- 2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-keto acid (KDO). It binds to bacterial glycans and helps defend against microorganisms. Intelectin-1/ITLN1 Protein, Human (N-His, C-myc) is the recombinant human-derived Intelectin-1/ITLN1 protein, expressed by E. coli , with N-10*His, C-Myc labeled tag. The total length of Intelectin-1/ITLN1 Protein, Human (N-His, C-myc) is 280 a.a., with molecular weight of ~38.6 kDa.

Intelectin-1/ITLN1 蛋白作为一种凝集素，以钙依赖性方式对微生物碳水化合物链具有特定的亲和力。它可识别含有末端无环 1,2-二醇部分的微生物聚糖，例如 β 连接的 D-呋喃半乳糖 (β-Galf)、D-磷酸甘油修饰聚糖、D-甘油-D-talo-oct-2-ulosonic 酸(KO) 和 3-脱氧-D-甘露-辛-2-酮酸 (KDO)。这种凝集素可与革兰氏阳性和革兰氏阴性细菌中发现的聚糖结合，包括肺炎克雷伯菌、肺炎链球菌、鼠疫耶尔森氏菌、奇异疟原虫和寻常疟原虫，但对人类聚糖没有亲和力。Intelectin-1/ITLN1 可能有助于抵抗微生物的防御系统，可能作为脂肪因子发挥作用，在脂肪细胞中的葡萄糖摄取调节和胰岛素刺激的葡萄糖摄取中发挥潜在作用。无论是否存在胰岛素，它都能增强 AKT 磷酸化。此外，Intelectin-1/ITLN1 可能与乳铁蛋白/LTF 相互作用，增加其摄取并可能在铁吸收中发挥作用。该蛋白质通过二硫键形成同源三聚体，并可能与乳铁蛋白/LTF 相互作用。

Human

E. coli

N-10*His;C-Myc

Q8WWA0 (T19-S298)

55600

Approximately 38.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.