JAML/AMICA 蛋白, Mouse (HEK293, His)

JAML/AMICA protein is a transmembrane protein on leukocytes that regulates migration and activation by interacting with CXADR on adjacent epithelial/endothelial cells. It is essential for the activation of γ-δ T cells in the epithelium, signaling through PI3 kinase and MAP kinase to promote T cell proliferation, cytokine/growth factor production, and tissue repair. JAML/AMICA Protein, Mouse (HEK293, His) is the recombinant mouse-derived JAML/AMICA protein, expressed by HEK293 , with C-His labeled tag. The total length of JAML/AMICA Protein, Mouse (HEK293, His) is 281 a.a., with molecular weight of ~47.7 KDa.

类连接粘附分子 (JAML)，也称为 AMICA，是一种位于白细胞质膜上的跨膜蛋白，通过与 CXADR（相邻上皮细胞和内皮细胞上存在的受体）相互作用来控制白细胞的迁移和激活。这种相互作用在激活 γ-δ T 细胞（一种存在于上皮细胞中的 T 细胞亚群）中发挥着至关重要的作用，有助于组织稳态和修复。与上皮 CXADR 结合后，JAML 通过 PI3 激酶和 MAP 激酶启动 γ-δ T 细胞中的下游信号传导，导致 T 细胞增殖以及刺激组织修复的细胞因子和生长因子的产生。JAML 还通过与上皮和内皮 CXADR 的粘附相互作用来调节上皮和内皮组织内白细胞的迁移。在其同型二聚体形式中，JAML 在介导白细胞-内皮细胞粘附方面特别活跃。此外，JAML 与整合素 α-4/β-1（ITGA4 和 ITGB1）相互作用，表明 JAML 通过控制 JAML 同二聚化在调节白细胞-内皮细胞粘附中发挥作用。

Mouse

HEK293

C-His

Q80UL9 (M1-L281)

270152  [NCBI]

Approximately 47.7 kDa.

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.