KIR2DL1 蛋白, Human (HEK293, His)

KIR2DL1, found on NK cells, serves as a receptor for specific HLA-C alleles, inhibiting NK cell activity to prevent cell lysis. This regulatory function involves interactions with ARRB2 and, additionally, engages PTPN6 and PTPN11. The interaction's enhancement by ARRB2 underscores KIR2DL1's role in complex signaling networks that modulate NK cell function. KIR2DL1 Protein, Human (HEK293, His) is the recombinant human-derived KIR2DL1 protein, expressed by HEK293 , with C-His labeled tag.

KIR2DL1 位于自然杀伤 (NK) 细胞上，充当特定 HLA-C 等位基因（包括 w4 和 w6）的受体，最终抑制 NK 细胞活性以防止细胞裂解。这种调节作用是通过与 ARRB2 的相互作用来促进的。此外，KIR2DL1 与 PTPN6 和 PTPN11 结合，ARRB2 增强了这种相互作用，进一步强调了它参与调节 NK 细胞功能的复杂信号网络。

Human

HEK293

C-His

P43626-1/NP_055033.2 (H22-H245)

3802  [NCBI]

Approximately 45 kDa

Greater than 90% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.