KLRG1 蛋白, Human (His-SUMO)

KLRG1 Protein exerts inhibitory effects on NK cells and T-cells by binding to their non-MHC ligands, potentially recognizing "missing self" through conserved sites on classical cadherins like E-cadherin/CDH1, N-cadherin/CDH2, and R-cadherin/CDH4. Existing as a monomer and homodimer connected by disulfide bonds, KLRG1 interacts with PTPN11 and INPP5D via its ITIM motif, suggesting involvement in signal transduction pathways. KLRG1 Protein, Human (His-SUMO) is the recombinant human-derived KLRG1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of KLRG1 Protein, Human (His-SUMO) is 136 a.a., with molecular weight of ~31.5 kDa.

KLRG1 蛋白通过与自然杀伤 (NK) 细胞和 T 细胞的非 MHC 配体结合，对自然杀伤 (NK) 细胞和 T 细胞的功能发挥抑制作用。它可能通过与经典钙粘蛋白上的保守位点结合来识别“缺失的自我”，专门监测靶细胞上 E-钙粘蛋白/CDH1、N-钙粘蛋白/CDH2 和 R-钙粘蛋白/CDH4 的表达。KLRG1 形成通过二硫键连接的单体和同二聚体。此外，它通过其 ITIM 基序与 PTPN11 和 INPP5D 相互作用，可能参与信号转导途径。

Human

E. coli

N-SUMO;N-6*His

Q96E93 (L60-F195)

10219  [NCBI]

LCQGSNYSTCASCPSCPDRWMKYGNHCYYFSVEEKDWNSSLEFCLARDSHLLVITDNQEMSLLQVFLSEAFCWIGLRNNSGWRWEDGSPLNFSRISSNSFVQTCGAINKNGLQASSCEVPLHWVCKKCPFADQALF

Approximately 31.5 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm sterile filtered 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.