2. 重组蛋白
  3. Enzymes & Regulators Ubiquitin Related Proteins
  4. Transferases (EC 2) Ubiquitin Enzymes
  5. E3 Ligases
  6. KMT2D 蛋白, Human

KMT2D 蛋白, Human

目录号: HY-P701589
产品使用指南

KMT2D 蛋白是一种组蛋白甲基转移酶，可甲基化组蛋白 H3“Lys-4”(H3K4)，主要在活性染色质位点建立 H3K4me1 标记。它是染色质重塑的一部分，作为雌激素受体的共激活剂，由 ESR1 招募，激活转录。KMT2D 在基因组位置沉积特定组蛋白标记的作用强调了它在调节染色质结构和基因表达中的重要作用。KMT2D 蛋白, Human 是重组的 KMT2D 蛋白，由 E. coli 表达，不带标签。KMT2D 蛋白, Human 全长 155 个氨基酸。

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规格 是否有货
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100 μg   询价  

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描述

KMT2D Protein, a histone methyltransferase, methylates histone H3 'Lys-4' (H3K4), predominantly establishing H3K4me1 marks at active chromatin sites. Integral to chromatin remodeling, it functions as a coactivator for the estrogen receptor, recruited by ESR1, activating transcription. KMT2D's role in depositing specific histone marks at genomic locations underscores its crucial involvement in modulating chromatin structure and gene expression. KMT2D Protein, Human is the recombinant human-derived KMT2D protein, expressed by E. coli , with tag free. The total length of KMT2D Protein, Human is 155 a.a., .
研究背景

KMT2D 蛋白是一种组蛋白甲基转移酶，负责协调甲基从 S-腺苷-L-甲硫氨酸转移到组蛋白 H3 (H3K4) 上“Lys-4”的ε-氨基。作为染色质重塑机制的一部分，它主要在与转录和 DNA 修复过程相关的活性染色质位点建立 H3K4me1 甲基化标记。KMT2D 作为雌激素受体的共激活剂，被 ESR1 招募，从而激活转录。该酶在功能相关的基因组位置沉积特定组蛋白标记的活性强调了其在调节染色质结构和基因表达中的关键作用。
种属

Human
表达系统

E. coli
标签

Tag Free
蛋白编号

O14686 (H5382-M5536)
基因 ID

8085
蛋白结构
N-term
KMT2D (H5382-M5536)
Accession # O14686
C-term
同用名
KMT2D; Histone-lysine N-methyltransferase 2D; Lysine N-methyltransferase 2D; ALL1-related protein; Myeloid/lymphoid or mixed-lineage leukemia protein 2
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

KMT2D Protein, Human 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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