L-selectin/CD62L 蛋白, Cynomolgus (HEK293, Fc)

L-selectin/CD62L, a calcium-dependent lectin, aids cell adhesion by binding neighboring glycoproteins. It mediates lymphocyte adherence to endothelial cells in peripheral lymph nodes, enabling leukocyte tethering and rolling. Interaction with SELPLG/PSGL1 and PODXL2 is vital for leukocyte recruitment and rolling, dependent on sialyl Lewis X glycan modification and tyrosine sulfation of SELPLG. Notably, sulfation on 'Tyr-51' of SELPLG is critical for L-selectin binding. L-selectin/CD62L Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived L-selectin/CD62L protein, expressed by HEK293 , with C-hFc labeled tag. The total length of L-selectin/CD62L Protein, Cynomolgus (HEK293, Fc) is 304 a.a., with molecular weight of ~85 & 35 kDa, respectively.

L-选择素是一种钙依赖性凝集素，通过与邻近细胞上的糖蛋白结合来促进细胞粘附。它在外周淋巴结高位内皮微静脉中淋巴细胞与内皮细胞的粘附中发挥重要作用，并促进内皮组织中白细胞的初始束缚和滚动。 L-选择素与 SELPLG/PSGL1 和 PODXL2 之间的相互作用对于白细胞的募集和滚动至关重要，这依赖于 SELPLG 和 PODXL2 的唾液酸 Lewis X 聚糖修饰以及 SELPLG 的酪氨酸硫酸化修饰。值得注意的是，SELPLG 'Tyr-51' 上的硫酸化对于 L-选择素的结合特别重要。

Cynomolgus

HEK293

C-hFc

Q95198 (D29-N332)

701419  [NCBI]

Approximately 85&35 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.