Langerin/CD207 蛋白, Rhesus Macaque (HEK293, Fc)

Langerin, also known as CD207, is a calcium-dependent lectin with mannose-binding specificity. Notably, it induces the formation of Birbeck granules (BG) and acts as an effective regulator of membrane stacking and zipping. Langerin/CD207 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived Langerin/CD207 protein, expressed by HEK293 , with N-hFc labeled tag.

Langerin，也称为 CD207，是一种钙依赖性凝集素，对甘露糖具有特定的亲和力。这种蛋白质在抗原摄取和加工中起着至关重要的作用。Langerin 诱导伯贝克颗粒 (BG) 的形成，并充当膜叠加和拉链的有效调节剂。它不仅具有与甘露糖化聚糖的结合能力，而且还具有与硫酸角质素 (KS) 和 β-葡聚糖等硫酸化聚糖的结合能力。作为同源三聚体，Langerin 促进抗原的摄取，并参与抗原呈递给 T 细胞的路径和处理。Langerin 的多方面功能凸显了其在免疫反应调节和抗原呈递途径中的重要性。

Measured by its binding ability in a functional ELISA. Immobilized Rhesus Macaque CD207, at 2 μg/mL (100 μL/well) can bind Anti-CD207 antibody. The ED₅₀ for this effect is 94.98 ng/mL.

Rhesus Macaque

HEK293

N-hFc

EHH22200.1 (P65-P328)

/

PRFMGNISDVKTNVQLLKGRVDNISTLDSEIKKNSDGMEAAGVQIQTVNVSLGYVRSQFLKLKTSVEKANAQIQILTRSWEEVGTLNAQIPELKSDLEKASALNTKIRALQGSLDNMSKLLKRQNDILQVVSQGWKYFKGNFYYFSLVTKTWYSAQQFCVSRNSHLTSVTSESEQEFLYKTAGGLTYWIGLTKAGMEGDWFWVDDTPFDKVQSAKFWIPGEPNNAGNNEHCGNIRVSSLQAWNDAQCDKTFLFICKRPYIPSEP

Approximately 65-80 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.