LDLRAD3 蛋白, Human (HEK293, hFc)

LDLRAD3 protein significantly affects the processing of amyloid precursor protein (APP), possibly reducing soluble APP-α (sAPP-α) and increasing the production of amyloid P3 peptide. Suggested regulation of ITCH and NEDD4 E3 ligases. LDLRAD3 Protein, Human (HEK293, hFc) is the recombinant human-derived LDLRAD3, expressed by HEK293 , with C-hFc labeled tag. ,

LDLRAD3 蛋白似乎对淀粉样前体蛋白 (APP) 的加工有显着影响，可能导致可溶性 APP-α (sAPP-α) 的产生减少，并增加淀粉样蛋白 P3 肽的产生。此外，研究表明，它在 ITCH 和 NEDD4 E3 连接酶的活性和降解中发挥调节作用。在微生物感染的情况下，LDLRAD3 充当委内瑞拉马脑炎病毒的受体。这些发现强调了 LDLRAD3 的多功能性质，表明它参与与蛋白质加工、免疫反应和病毒相互作用相关的关键细胞过程。

Measured by its binding ability in a functional ELISA. Immobilized human ITCH at 2μg/mL (100μL/well) can bind Biotinylated Human LDLRAD3. The ED₅₀ for this effect is 1.503 μg/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized human ITCH at 2μg/mL (100μL/well) can bind Biotinylated Human LDLRAD3. The ED₅₀ for this effect is 1.503 μg/mL.

Human

HEK293

C-hFc

Q86YD5-1 (Q18-T173)

143458

QLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGSGQVFVTSENQLVYYPSIT

Approximately 55 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.