2. 重组蛋白
  3. CD Antigens Receptor Proteins
  4. Epithelial cell CD Proteins
  5. LIF-R/CD118
  6. LIFR 蛋白, Human (HEK293, hFc-Flag)

LIFR 蛋白, Human (HEK293, hFc-Flag)

目录号: HY-P700418
产品使用指南

LIFR 蛋白是一种信号转导分子，可能与 IL6ST 共享共同通路。其可溶形式抑制 LIF 与靶细胞受体的结合，从而降低生物活性。LIFR 与 IL6ST 形成异二聚体，与 CNTF 和 CNTFR 复合物相互作用，这意味着细胞过程中潜在的串扰和协作作用。LIFR 蛋白, Human (HEK293, hFc-Flag) 是重组的 LIFR 蛋白，由 HEK293 表达，带有 C-hFc, C-Flag 标签。

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规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

LIFR Protein, a signal-transducing molecule, potentially shares a common pathway with IL6ST. Its soluble form inhibits LIF binding to target cell receptors, reducing biological activity. LIFR forms a heterodimer with IL6ST, interacting with the CNTF and CNTFR complex, implying potential crosstalk and collaborative actions in cellular processes. LIFR Protein, Human (HEK293, hFc-Flag) is the recombinant human-derived LIFR protein, expressed by HEK293 , with C-hFc, C-Flag labeled tag.
研究背景

LIFR 蛋白作为信号转导分子，可能与 IL6ST 具有共同的通路。其可溶形式可作为抑制剂，阻断 LIF 与靶细胞上受体的结合，从而抑制其生物活性。LIFR 与 IL6ST 形成异二聚体，并且该异二聚体与 CNTF 和 CNTFR 形成的复合物相互作用，表明细胞过程中潜在的串扰和协作作用。
种属

Human
表达系统

HEK293
标签

C-hFc;C-Flag
蛋白编号

P42702-1 (M45-S833)
基因 ID
蛋白结构
N-term
LIFR (M45-S833)
Accession # P42702-1
hFc-Flag
C-term
同用名
LIFR; leukemia inhibitory factor receptor alpha; leukemia inhibitory factor receptor; CD118; LIF receptor; CD118 antigen; SWS; SJS2; STWS; LIF-R; FLJ98106; FLJ99923;
氨基酸序列

QKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENS

分子量

119.3 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

LIFR Protein, Human (HEK293, hFc-Flag) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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