LILRA2/CD85h/ILT1 蛋白, Human (HEK293, His)

LILRA2/CD85h/ILT1 protein is pivotal in innate immune responses, recognizing N-terminally truncated immunoglobulins from various pathogenic bacteria and fungi. It interacts with cleaved IgM, IgG3, and IgG4, triggering neutrophil and monocyte activation. In eosinophils, ligand binding induces the release of RNASE2, IL4, and leukotriene C4. Importantly, LILRA2 exists as a homodimer, selectively binding to microbial-derived ligands and modulating immune responses in a ligand-specific manner. LILRA2/CD85h/ILT1 Protein, Human (HEK293, His) is the recombinant human-derived LILRA2/CD85h/ILT1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LILRA2/CD85h/ILT1 Protein, Human (HEK293, His) is 397 a.a., with molecular weight of ~66.0 kDa.

LILRA2/CD85h/ILT1 蛋白在针对微生物感染的先天免疫反应中发挥着至关重要的作用。它特异性识别由各种致病细菌和真菌（包括嗜肺军团菌、猪鼻支原体、肺炎链球菌、金黄色葡萄球菌和白色念珠菌）中的蛋白酶裂解产生的 N 末端截短的免疫球蛋白子集。该蛋白与部分位于免疫球蛋白轻链可变区的表位结合，需要恒定区来进行信号传导。 LILRA2 与裂解的 IgM、IgG3 和 IgG4 相互作用，但不与裂解的 IgA1 结合。通过结合 N 末端截短的免疫球蛋白进行激活，触发中性粒细胞激活，导致各种细胞因子和趋化因子的释放。在单核细胞中，这种激活诱导 CSF2、CF3、IL6、CXCL8 和 CCL3 的释放，同时可能通过下调 TLR4 表达来下调对细菌脂多糖 (LPS) 的反应。此外，在嗜酸性粒细胞中，配体结合导致 RNASE2、IL4 和白三烯 C4 的释放。重要的是，LILRA2 不与 I 类 MHC 抗原结合，并以同二聚体形式存在。

Human

HEK293

C-6*His

Q8N149-2 (G24-S420)

11027  [NCBI]

GHLPKPTLWAEPGSVIIQGSPVTLRCQGSLQAEEYHLYRENKSASWVRRIQEPGKNGQFPIPSITWEHAGRYHCQYYSHNHSSEYSDPLELVVTGAYSKPTLSALPSPVVTLGGNVTLQCVSQVAFDGFILCKEGEDEHPQRLNSHSHARGWSWAIFSVGPVSPSRRWSYRCYAYDSNSPYVWSLPSDLLELLVPGVSKKPSLSVQPGPMVAPGESLTLQCVSDVGYDRFVLYKEGERDFLQRPGWQPQAGLSQANFTLGPVSPSHGGQYRCYSAHNLSSEWSAPSDPLDILITGQFYDRPSLSVQPVPTVAPGKNVTLLCQSRGQFHTFLLTKEGAGHPPLHLRSEHQAQQNQAEFRMGPVTSAHVGTYRCYSSLSSNPYLLSLPSDPLELVVSAS

Approximately 66.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.