LILRB3/CD85a 蛋白, Human (HEK293, Fc)

LILRB3/CD85a protein, as a receptor for class I MHC antigens, plays an indispensable role in immune recognition. Activation of LILRB3 occurs through binding to immune receptors such as FCGR2B and B cell receptors, resulting in downregulation of antigen-induced B cell activation. LILRB3/CD85a Protein, Human (HEK293, Fc) is the recombinant human-derived LILRB3/CD85a protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LILRB3/CD85a Protein, Human (HEK293, Fc) is 420 a.a., with molecular weight of ~72.9 kDa.

LILRB3/CD85a 蛋白似乎充当 I 类 MHC 抗原的受体，突出了其在免疫识别中的不可或缺的作用。LILRB3 的激活是在与 FCGR2B 和 B 细胞受体等免疫受体结合时触发的。这种激活通过将磷酸酶募集到基于酪氨酸的免疫受体抑制剂基序 (ITIM) 来下调抗原诱导的 B 细胞激活。该蛋白进一步与包括 LYN、PTPN6/SHP-1 和 PTPN11/SHP-2 在内的关键信号分子相互作用，强调其参与调节免疫反应的复杂信号级联反应。全面探索 LILRB3 的相互作用及其对免疫受体活性的调节可以增强我们对其功能的理解以及对 B 细胞激活和免疫调节微调的潜在影响。

Human

HEK293

C-hFc

AAI04994.1 (G24-E443)

102725035  [NCBI]

GPFPKPTLWAEPGSVISWGSPVTIWCQGSLEAQEYRLDKEGSPEPLDRNNPLEPKNKARFSIPSMTEHHAGRYRCHYYSSAGWSEPSDPLELVMTGFYNKPTLSALPSPVVASGGNMTLRCGSQKGYHHFVLMKEGEHQLPRTLDSQQLHSGGFQALFPVGPVNPSHRWRFTCYYYYMNTPQVWSHPSDPLEILPSGVSRKPSLLTLQGPVLAPGQSLTLQCGSDVGYDRFVLYKEGERDFLQRPGQQPQAGLSQANFTLGPVSRSHGGQYRCYGAHNLSSEWSAPSDPLNILMAGQIYDTVSLSAQPGPTVASGENVTLLCQSWWQFDTFLLTKEGAAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAGTYRCYGSYSSNPHLLSFPSEPLELMVSGHSGGSSLPPTGPPSTPGLGRYLE

Approximately 90-110 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.