LRP-1 Cluster II 蛋白, Human (HEK293, His)

LRP-1 Cluster II protein is involved in endocytosis and phagocytosis of apoptotic cells. The LRP-1 Cluster II protein also serves as a receptor for Pseudomonas aeruginosa exotoxin A during microbial infection. LRP-1 Cluster II Protein, Human (HEK293, His) is the recombinant human-derived LRP-1 Cluster II protein, expressed by HEK293 , with C-10*His labeled tag. The total length of LRP-1 Cluster II Protein, Human (HEK293, His) is 380 a.a., .

LRP-1 Cluster II 蛋白作为多功能内吞受体出现，在凋亡细胞的内吞作用和吞噬作用中发挥关键作用。其重要性延伸至早期胚胎发育和细胞脂质稳态的基本功能。此外，LRP-1 Cluster II 积极参与乳糜微粒残余物和激活的 LRPAP1（α2-巨球蛋白）的血浆清除，以及纤溶酶原激活剂与其内源性抑制剂之间形成的复合物的局部代谢。作为 LRPAP1 α-2-巨球蛋白受体，它进一步参与各种细胞事件，包括 TAU/MAPT 的内吞作用和随后的扩散。此外，LRP-1 Cluster II 可以调节关键的细胞过程，例如 APP 代谢、激酶依赖性细胞内信号传导、神经元钙信号传导和神经传递。值得注意的是，在微生物感染中，该蛋白作为铜绿假单胞菌外毒素 A 的受体发挥作用，突出了其在细胞生理学和宿主-病原体相互作用中的多样化和复杂的作用。

Measured by its binding ability in a functional ELISA. When Recombinant LRP-1 Cluster II Protein is immobilized at 50 ng/mL (100 μL/well) can bind Recombinant Human LRPAP (HY-P76478). The ED₅₀ for this effect is 2.302 ng/mL.

Human

HEK293

C-10*His

Q07954 (R786-L1165)

4035

RPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKL

Approximately 65-80 kDa due to the glycosylation.

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in PBS. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.