LRPAP1 蛋白, Human (HEK293, His)

The LRPAP1 protein serves as a molecular chaperone for LDL receptor-related proteins and regulates ligand binding throughout the secretory pathway. It transiently interacts with the LRP1/α-2-macroglobulin receptor chain, reducing ligand binding. LRPAP1 Protein, Human (HEK293, His) is the recombinant human-derived LRPAP1 protein, expressed by HEK293 , with C-His labeled tag. The total length of LRPAP1 Protein, Human (HEK293, His) is 323 a.a., with molecular weight of ~43 KDa.

LRPAP1 蛋白作为 LDL 受体相关蛋白的分子伴侣，有助于在整个分泌途径中调节其配体结合活性。值得注意的是，LRPAP1 与 LRP1/α-2-巨球蛋白受体重链和轻链发生短暂的相互作用，与受体配体结合的减少同时发生。此外，LRPAP1 与 LRP2/糖蛋白 330、LDLR 和 SORL1 形成相互作用，产生从内化和降解到调节配体结合等多种结果。复杂的相互作用网络强调了 LRPAP1 在协调 LDL 受体相关蛋白的功能和运输中的多方面作用。

Measured by its binding ability in a functional ELISA. Immobilized human LRPAP1 at 0.5 μg/mL can bind human VLDLR with a range of 3.2-400 ng/mL.

Human

HEK293

C-His

P30533 (Y35-L357)

4043  [NCBI]

Approximately 43 kDa.

Greater than 90% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.