1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Chemokine & Receptors
  4. CC Chemokines
  5. MCP-1/CCL2
  6. MCP-1/CCL2 蛋白, Cynomolgus (HEK293, His)

MCP-1/CCL2 蛋白, Cynomolgus (HEK293, His)

目录号: HY-P700787
产品使用指南

MCP-1/CCL2 蛋白激活 CCR2 并诱导趋化性和钙离子动员。它吸引单核细胞和嗜碱性粒细胞,而不是中性粒细胞或嗜酸性粒细胞。它还会导致神经性疼痛并增强多巴胺神经元的突触传递。MCP-1/CCL2 以单体或同二聚体形式存在,并通过蛋白聚糖与内皮细胞结合。它通过其 Link 域与 TNFAIP6 相互作用。MCP-1/CCL2 蛋白, Cynomolgus (HEK293, His) 是重组的 MCP-1/CCL2 蛋白,由 HEK293 表达,带有 C-His 标签。MCP-1/CCL2 蛋白, Cynomolgus (HEK293, His) 全长 76 个氨基酸,分子量为 13-16 kDa。

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描述

MCP-1/CCL2 protein activates CCR2 and induces chemotaxis and calcium ion mobilization. It attracts monocytes and basophils, not neutrophils or eosinophils. It also contributes to neuropathic pain and enhances synaptic transmission in dopamine neurons. MCP-1/CCL2 exists as a monomer or homodimer and binds to endothelial cells through proteoglycans. It interacts with TNFAIP6 via its Link domain. MCP-1/CCL2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived MCP-1/CCL2 protein, expressed by HEK293, with C-His labeled tag. The total length of MCP-1/CCL2 Protein, Cynomolgus (HEK293, His) is 76 a.a., with molecular weight of 13-16 kDa.

研究背景

MCP-1/CCL2 蛋白作为 CC 趋化因子受体 CCR2 的配体,导致 CCR2 的激活和结合,随后诱导强烈的趋化反应和细胞内钙离子的动员。它显示出专门针对单核细胞和嗜碱性粒细胞的趋化活性,但不针对中性粒细胞或嗜酸性粒细胞。此外,MCP-1/CCL2 在介导周围神经损伤引起的神经病理性疼痛中发挥着至关重要的作用。它可能通过 GRIN2B/NMDAR2B 的 MAPK/ERK 依赖性磷酸化增强含有多巴胺 D1 和 D2 受体的神经元中 NMDA 介导的突触传递。MCP-1/CCL2 以单体或同二聚体形式存在,通过蛋白聚糖的糖胺聚糖 (GAG) 侧链促进其在内皮细胞上的存在。此外,它通过其 Link 域与 TNFAIP6 相互作用。

种属

Cynomolgus

表达系统

HEK293

标签

C-His

蛋白编号

P61274 (Q24-P99)

基因 ID
蛋白结构
N-term
CCL2 (Q24-P99)
Accession # P61274
His
C-term
同用名
C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2
分子量

13-16 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

MCP-1/CCL2 Protein, Cynomolgus (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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MCP-1/CCL2 Protein, Cynomolgus (HEK293, His)
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HY-P700787
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