Menin 蛋白, Human (His, T349M)

The Menin protein is an important component of the MLL/SET1 HMT complex, which methylates “Lys-4” of histone H3. It acts as a transcriptional regulator, inhibiting telomerase expression and inhibiting cell proliferation through TGFB1. Menin Protein, Human (His, T349M) is the recombinant human-derived Menin, expressed by E. coli , with His labeled tag. ,

Menin 作为 MLL/SET1 组蛋白甲基转移酶 (HMT) 复合物中的关键成分出现，在甲基化组蛋白 H3 (H3K4) 的“Lys-4”方面具有特异性，从而充当转录调节因子。其调节影响延伸至 TERT 启动子，抑制端粒酶表达，并延伸至 TGFB1 介导的细胞增殖抑制，可能调节 SMAD3 转录活性。Menin 的全部功能包括抑制 JUND 介导的 AP1 位点和 NFKB 亚基 RELA 转录激活，以及 HOXC8 和 HOXC6 基因表达的正向调节。它可能通过激活 HOXA9 表达来促进正常造血。此外，Menin 参与 DNA 修复又增加了其功能复杂性。在 MLL-HCF 复合体和 menin 相关组蛋白甲基转移酶复合体中，Menin 与 KMT2A/MLL1、ASH2L、RBBP5、DPY30、WDR5、HCFC1、HCFC2 等蛋白质网络协作。值得注意的相互作用包括与 POLR2B、POLR2A、FANCD2、DBF4、JUND、SMAD3、NFKB1、NFKB2、RELA 和 KMT2A 的相互作用，突出了 Menin 多种功能背后复杂的分子关系网络。

Human

E. coli

N-His

O00255-1 (M1-L615, T349M)

4221

Approximately 69 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl (pH 7.5), 200 mM NaCl, 20% glycerol, 1 mM DTT.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.