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  3. MEPE/OF45 蛋白, Mouse (HEK293, His)

MEPE/OF45 蛋白, Mouse (HEK293, His)

目录号: HY-P77996
产品使用指南

MEPE/OF45 蛋白对于调节肾脏磷酸盐和尿酸排泄至关重要,影响成骨细胞和软骨细胞的骨矿化,对颅面结构具有显着影响。其在牙髓干细胞增殖中的作用显着。MEPE/OF45 与 PHEX 的相互作用由其 ASARM 基序介导,是锌依赖性的,这增加了其调节功能的复杂性。MEPE/OF45 蛋白, Mouse (HEK293, His) 是重组的 MEPE/OF45 蛋白,由 HEK293 表达,带有 C-His 标签。MEPE/OF45 蛋白, Mouse (HEK293, His) 全长 417 个氨基酸,分子量为 45-60 kDa。

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描述

MEPE/OF45 Protein, pivotal in regulating renal phosphate and uric acid excretion, influences bone mineralization in osteoblasts and chondrocytes, with notable effects on craniofacial structures. Its role in dental pulp stem cell proliferation is significant. MEPE/OF45's interaction with PHEX, mediated by its ASARM motif, is zinc-dependent, adding complexity to its regulatory functions. MEPE/OF45 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MEPE/OF45 protein, expressed by HEK293 , with C-His labeled tag. The total length of MEPE/OF45 Protein, Mouse (HEK293, His) is 417 a.a., with molecular weight of 45-60 kDa.

研究背景

MEPE/OF45蛋白在肾磷酸盐和尿酸排泄的调节中发挥着关键作用。它的影响延伸到骨矿化的复杂过程,影响成骨细胞和软骨细胞。MEPE/OF45 对细胞外基质矿化的影响在颅面结构(包括牙齿、骨骼和软骨)中尤其显着。此外,它有助于牙髓干细胞的增殖。该蛋白与 PHEX 的相互作用由其 ASARM 基序介导,取决于锌,这为其调节功能增加了一层复杂性。

种属

Mouse

表达系统

HEK293

标签

C-His

蛋白编号

Q8K4L6 (A25-D441)

基因 ID
蛋白结构
N-term
MEPE (A25-D441)
Accession # Q8K4L6
His
C-term
同用名
OF45; MEPE; Osteoregulin
分子量

45-60 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

MEPE/OF45 Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
MEPE/OF45 Protein, Mouse (HEK293, His)
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HY-P77996
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