METRNL/Meteorin-like 蛋白, Human (His-SUMO)

METRNL/meteorin-like protein is caused by hormonal changes caused by exercise or cold exposure, which increases energy expenditure. After exercise, it is expressed in skeletal muscle, whereas during cold exposure, it is expressed in adipose tissue. METRNL/Meteorin-like Protein, Human (His-SUMO) is the recombinant human-derived METRNL/Meteorin-like protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

METRNL/镍纹蛋白样蛋白是响应运动或暴露于寒冷引发的荷尔蒙变化而诱导的，有助于增加能量消耗。它在运动后的骨骼肌和寒冷暴露期间的脂肪组织中观察到其表达，并在血液中循环。METRNL/镍纹蛋白样蛋白通过促进白色脂肪库褐变和改善葡萄糖耐量来促进能量消耗。有趣的是，它的产热作用并不直接作用于脂肪细胞，而是涉及刺激各种免疫细胞亚型。它诱导嗜酸性粒细胞依赖性 IL4 表达增加，并促进脂肪组织巨噬细胞的替代激活，这对于增强脂肪中生热和抗炎基因程序的表达至关重要。METRNL/镍纹蛋白样蛋白对于某些寒冷诱导的生热反应至关重要，突出了其在低温代谢适应中的作用。

Human

E. coli

N-SUMO;N-6*His

Q641Q3-1 (Q46-D311)

284207  [NCBI]

QYSSDRCSWKGSGLTHEAHRKEVEQVYLRCAAGAVEWMYPTGALIVNLRPNTFSPARHLTVCIRSFTDSSGANIYLEKTGELRLLVPDGDGRPGRVQCFGLEQGGLFVEATPQQDIGRRTTGFQYELVRRHRASDLHELSAPCRPCSDTEVLLAVCTSDFAVRGSIQQVTHEPERQDSAIHLRVSRLYRQKSRVFEPVPEGDGHWQGRVRTLLECGVRPGHGDFLFTGHMHFGEARLGCAPRFKDFQRMYRDAQERGLNPCEVGTD

Approximately 46.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.