MGL2/CD301b 蛋白, Mouse (HEK293, His)

MGL2/CD301b is a type II lectin commonly used as a marker for alternatively activated macrophages. MGL2 can bind to terminal GalNAc residues, including the Tn antigen (GalNAc-αThr/Ser). MGL2 is mainly expressed on immature, tolerogenic or type-2 DCs and alternatively-activated macrophages^[1][2]. MGL2/CD301b Protein, Mouse (HEK293, His) is the recombinant mouse-derived MGL2/CD301b protein, expressed by HEK293, with N-6*His labeled tag. The total length of MGL2/CD301b Protein, Mouse (HEK293, His) is 261 a.a., with molecular weight of 30-40 kDa.

巨噬细胞 Gal/GalNAc 凝集素 2（MGL2 或 CD301）是一种 II 型凝集素，通常用作替代激活巨噬细胞的标记。MGL2 可以结合末端 GalNAc 残基，包括 Tn 抗原 (GalNAc-αThr/Ser)。MGL2 主要在未成熟、耐受性或 2 型 DC 以及替代激活的巨噬细胞上表达^[1][2]。此外，小鼠 MGL2 与腺癌细胞有强烈的相互作用，表明其在肿瘤免疫中的作用^[3]。

Mouse

HEK293

N-6*His

Q8JZN1 (S72-P332)

216864  [NCBI]

SQNSQLRRDLGTLRAILDNTTSKIKAEFQSLDSRADNFEKGISSLKVDVEDHRQELQAGRDLSQKVTSLESTLEKREQALKTDLSDLTDHVQQLETDLKALTCQLANLKNNGSEVACCPLHWTEHEGSCYWFSESEKSWPEADKYCRLENSHLVVVNSLEEQNFLQNRLANVLSWMGLTDQNGPWRWVDGTDFDKGFKNWRPLQPDNWHGHMLGGGEDCAHFSYDGRWNDDVCQRHYHWICETELGKASSAHSPQLIASVP

30-40 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.