MIP-3 alpha/CCL20 蛋白, Bovine (His-SUMO)

MIP-3 alpha/CCL20 Protein acts as a ligand for CCR6, inducing a potent chemotactic response and intracellular calcium mobilization upon CCR6 binding. Crucial in chemotaxis, the CCL20-CCR6 pair attracts dendritic cells, effector/memory T-cells, and B-cells, especially in skin and mucosal surfaces during homeostasis, inflammation, cancer, and autoimmune diseases. As a chemotactic factor, CCL20 selectively attracts lymphocytes, less so neutrophils, excluding monocytes. It recruits pro-inflammatory IL17-producing helper T-cells (Th17) and regulatory T-cells (Treg) to inflammation sites and is essential for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Additionally, it positively regulates sperm motility and chemotaxis by binding to CCR6, triggering Ca2+ mobilization in sperm for motility. CCL20 may contribute to the formation and function of mucosal lymphoid tissues by directing lymphocytes and dendritic cells to epithelial cells. MIP-3 alpha/CCL20 Protein, Bovine (His-SUMO) is the recombinant bovine-derived MIP-3 alpha/CCL20 protein, expressed by E. coli, with N-SUMO, N-6*His labeled tag. The total length of MIP-3 alpha/CCL20 Protein, Bovine (His-SUMO) is 70 a.a., with molecular weight of 24.1 kDa.

MIP-3 α/CCL20 蛋白作为 CC 趋化因子受体 CCR6 的配体，在 CCR6 结合和激活后启动有效的趋化反应并动员细胞内钙离子。CCL20-CCR6 配体-受体对在趋化性、吸引树突状细胞 (DC)、效应/记忆 T 细胞和 B 细胞中发挥着至关重要的作用。这种伙伴关系对于各种条件下的皮肤和粘膜表面尤其重要，包括稳态、炎症、癌症和自身免疫性疾病。作为趋化因子，CCL20 特异性吸引淋巴细胞，并在较小程度上吸引中性粒细胞（不包括单核细胞）。此外，它还参与将产生促炎性 IL17 的辅助 T 细胞 (Th17) 和调节性 T 细胞 (Treg) 募集到炎症部位。CCL20 对于胸腺天然调节性 T 细胞 (nTreg) 和 DN1 早期胸腺祖细胞的最佳迁移至关重要。此外，它通过与 CCR6 结合，触发精子中 Ca2+ 的动员，这是精子活力的关键因素，从而积极调节精子的活力和趋化性。CCL20 还可能通过引导淋巴细胞和树突细胞朝向上皮细胞来促进粘膜淋巴组织的形成和功能。

Bovine

E. coli

N-SUMO;N-6*His

Q8SQB1 (A27-M96)

281666  [NCBI]

ASNFDCCLRYTERILHPSILVGFTQQLANEACDINAVVFYTRKKLAVCADPKKKWVKQVVHMLSQRVKRM

24.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.