MMP-8 蛋白, Human (HEK293)

MMP-8, also known as matrix metalloproteinase-8 or collagenase-2, is recognized for its enzymatic abilities, particularly its ability to break down fibrillar types I, II, and III collagen. This enzymatic activity suggests that MMP-8 plays an important role in the remodeling and turnover of collagen-rich tissues such as connective tissue, cartilage, and bone. MMP-8 Protein, Human (HEK293) is the recombinant human-derived MMP-8 protein, expressed by HEK293 , with N-Met labeled tag. The total length of MMP-8 Protein, Human (HEK293) is 447 a.a., with molecular weight of ~65 kDa.

MMP-8，也称为基质金属蛋白酶-8 或胶原酶-2，因其酶促能力，特别是其分解纤维状 I、II 和 III 型胶原蛋白的能力而受到认可。这种酶活性表明 MMP-8 在富含胶原蛋白的组织（如结缔组织、软骨和骨）的重塑和周转中发挥着重要作用。通过降解这些纤维状胶原蛋白，MMP-8 可以促进组织重塑、伤口愈合和炎症消退等过程。了解 MMP-8 的精确功能和调节可以为其参与胶原蛋白代谢和组织重塑提供有价值的见解，从而可能为以异常胶原蛋白降解或积累为特征的疾病提供治疗机会。

Measured by its ability to cleave the fluorogenic peptide substrate, Mca-PLGL-Dpa-AR-NH2 and the specific activity is > 250 pmoles/min/μg.

Human

HEK293

Tag Free

P22894 (F21-G467)

4317  [NCBI]

FPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG

Approximately 65 kDa

Greater than 90% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.