MXRA8 蛋白, Human (HEK293, His)

MXRA8 Protein, a transmembrane modulator, likely interacts with integrin ITGAV:ITGB3, influencing various signaling pathways. It inhibits osteoclastogenesis, promotes cartilage formation, and stimulates primary cilia formation in chondrocytes. In angiogenesis, it suppresses endothelial cell migration, promotes apoptosis, and inhibits VEGF-induced AKT and p38 MAP kinase activation. Additionally, MXRA8 may contribute to arthritogenic alphavirus pathogenesis as a viral receptor. MXRA8 Protein, Human (HEK293, His) is the recombinant human-derived MXRA8 protein, expressed by HEK293 , with C-His labeled tag. The total length of MXRA8 Protein, Human (HEK293, His) is 322 a.a., with molecular weight of 40-53 kDa.

MXRA8 是一种跨膜蛋白，可能通过与整合素 ITGAV:ITGB3 相互作用对各种信号通路发挥调节影响。这种相互作用促进异嗜性细胞间相互作用，并可能通过抑制整合素 ITGB3 和 MAP 激酶 p38 的信号传导来调节 TNFSF11/RANKL 和 CSF1 下游的破骨细胞生成。在软骨形成过程中，MXRA8促进生长板软骨细胞的增殖和成熟，刺激初级纤毛形成，并增强hedgehog信号通路基因（包括IHH）的表达。此外，MXRA8 通过抑制内皮细胞迁移、促进细胞凋亡以及抑制 VEGF 诱导的 AKT 和 p38 MAP 激酶激活，在血管生成中发挥作用。此外，MXRA8 还可抑制 VTN 响应下的整合素 ITGAV:ITGB3 信号传导和 PTK2/FAK 激活。它还可能有助于血脑屏障的成熟和维持。在微生物感染的情况下，MXRA8 作为致关节炎甲病毒的受体，促进其发病机制。

Human

HEK293

C-His

Q9BRK3-1 (V20-Q341)

/

40-53 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.