Natriuretic peptides A/NPPA 蛋白, Human (P. pastoris, His)

Natriuretic peptide A/NPPA is critical for cardiorenal homeostasis and regulates vascular remodeling and energy metabolism by binding to NPR1. This stimulates the production of c, activating PRKG1 to respond differently. Natriuretic peptides A/NPPA Protein, Human (P. pastoris, His) is the recombinant human-derived Natriuretic peptides A/NPPA protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Natriuretic peptides A/NPPA Protein, Human (P. pastoris, His) is 38 a.a., with molecular weight of 5.9 kDa.

利钠肽 A/NPPA 对心肾稳态至关重要，在血管重塑和能量代谢中发挥着多种作用。这些肽结合并刺激 NPR1，触发 cGMP 产生并激活下游效应器（包括 PRKG1），以介导各种生物反应。从功能上讲，它们调节血管舒张、尿钠排泄、利尿和醛固酮合成，这对于血压调节和液体电解质平衡至关重要。此外，它们还通过诱导心肌细胞凋亡和抑制细胞生长来抑制心脏重塑和肥大。怀孕期间，利钠肽 A/NPPA 促进滋养层侵袭和螺旋动脉重塑，预防妊娠高血压。在脂肪组织中，它们通过 cGMP 和 PKG 依赖性途径调节脂质代谢和能量稳态，影响 AMP 激活蛋白激酶 (AMPK) 并促进棕色脂肪组织中 UCP1 依赖性产热。与清除受体 NPR3 的相互作用有助于将其从循环中清除。虽然关于它们参与哺乳动物血容量和压力稳态的报道各不相同，但它们通过减少近端肾小管蛋白质重吸收来增强尿蛋白排泄。总体而言，利钠肽 A/NPPA 在维持多个系统的生理平衡方面发挥着关键作用。

Human

P. pastoris

N-6*His

P01160 (P78-L115)

4878  [NCBI]

PEVPPWTGEVSPAQRDGGALGRGPWDSSDRSALLKSKL

5.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.