Neogenin 蛋白, Human (HEK293, hFc)

Neogenin is a multifunctional cell surface receptor that controls multiple developmental processes by regulating cell adhesion. It affects neural tube and mammary gland formation, myogenesis and angiogenesis. Neogenin Protein, Human (HEK293, hFc) is the recombinant human-derived Neogenin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Neogenin Protein, Human (HEK293, hFc) is 1072 a.a., with molecular weight of 150-180 kDa.

Neogenin 是一种多功能细胞表面受体，通过调节细胞粘附来协调多种发育过程。它的影响涵盖神经管和乳腺形成、肌肉生成和血管生成。作为 BMP、netrin 和排斥引导分子 (RGM) 家族成员的受体，Neogenin 参与对细胞反应至关重要的复杂相互作用。值得注意的是，与 netrin 的相互作用会导致化学吸引性轴突引导反应和细胞间粘附，而与 RGMa 和 RGMb 的相互作用则会诱导化学脉冲反应。该受体还与 MYO10 相互作用，并与特定的 BMP（包括 BMP2、BMP4、BMP6 和 BMP7）形成关联。这种全面的相互作用网络强调了 Neogenin 在调节一系列关键发育环境中的细胞粘附方面的核心作用。

Immobilized Human RGMa, His Tag at 5 μg/mL (100 μl/Well) on the plate. Dose response curve for Human Neogenin, hFc Tag with the EC₅₀ of ≤0.5 μg/mL determined by ELISA.

Human

HEK293

C-hFc

Q92859-1 (A34-L1105)

/

150-180 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.