Noggin 蛋白, Mouse (HEK293, Fc)

Noggin is an indispensable factor in cartilage morphogenesis and joint formation, a potent inhibitor of bone morphogenetic protein (BMP) signaling, and plays a crucial role in the growth and patterning of the neural tube and somites.By forming homodimers, Noggin acts as a key regulator to inhibit chondrocyte differentiation by interacting with growth and differentiation factors, particularly GDF5 and possibly GDF6.Noggin Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Noggin protein, expressed by HEK293 , with C-hFc labeled tag.

Noggin 是一种参与软骨形态发生和关节形成的重要蛋白质，在抑制骨形态发生蛋白 (BMP) 信号传导方面发挥着至关重要的作用，而骨形态发生蛋白 (BMP) 对于神经管和体节的生长和模式形成至关重要。作为 BMP 的抑制剂，Noggin 通过与生长和分化因子 5 (GDF5) 以及可能的 GDF6 相互作用，参与软骨细胞分化的调节。Noggin 作为同二聚体存在，直接与 GDF5 相互作用，导致软骨细胞分化受到抑制。这些多方面的功能强调了 Noggin 在胚胎发育中的重要性，特别是在骨骼和神经组织形成的复杂过程中，并强调了它作为 BMP 信号通路关键调节剂的作用（参考：提供的信息）。

Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED₅₀ for this effect is 0.04-0.3 µg/mL in the presence of 50 ng/mL of recombinant Human BMP‑4.

Mouse

HEK293

C-hFc

P97466 (Q28-C232)

18121  [NCBI]

QHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDRPGGGGGPAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQMWLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRCQRRGGQRCGWIPIQYPIISECKCSC

55-65 kDa

Greater than 90% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.