Neuregulin-2/NRG2 蛋白, Human (HEK293, His)

Neuregulin-2/NRG2 protein serves as a direct ligand for the ERBB3 and ERBB4 tyrosine kinase receptors, initiating ligand-stimulated tyrosine phosphorylation and activation of these receptors. At the same time, NRG2 simultaneously recruits ERBB1 and ERBB2 coreceptors, possibly promoting heterodimerization with the EGF receptor. Neuregulin-2/NRG2 Protein, Human (HEK293, His) is the recombinant human-derived Neuregulin-2/NRG2 protein, expressed by HEK293 , with C-His labeled tag. The total length of Neuregulin-2/NRG2 Protein, Human (HEK293, His) is 293 a.a., with molecular weight of ~34 kDa.

Neuregulin-2 (NRG2) 作为酪氨酸激酶受体 ERBB3 和 ERBB4 的直接配体发挥作用。结合后，NRG2 促进 ERBB1 和 ERBB2 辅助受体的募集，导致配体诱导的酪氨酸磷酸化和 ERBB 受体的激活。此外，NRG2 可能促进与 EGF 受体的异二聚化。与 ERBB 家族成员的这种复杂的相互作用表明 NRG2 在通过激活下游信号通路来调节多种细胞过程中发挥着作用。NRG2 与 ERBB 受体的结合和激活强调了其在细胞通讯和信号转导中的重要性，强调了其在各种生理和发育环境中的潜在参与（参考文献不可用）。

Human

HEK293

C-His

O14511 (C112-K404)

9542  [NCBI]

Approximately 34 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.