ODC1 蛋白, Human (His-T7)

ODC (ornithine decarboxylase) is the rate-limiting enzyme in polyamine biosynthesis, catalyzing the conversion of ornithine to putrescine, a precursor of polyamines such as spermidine and spermine, which influence cell proliferation and various cellular processes. ODC1 Protein, Human (His-T7) is the recombinant human-derived ODC1 protein, expressed by E. coli , with N-T7, C-6*His labeled tag. The total length of ODC1 Protein, Human (His-T7) is 461 a.a., with molecular weight of 25 & 58 kDa, respectively.

ODC（鸟氨酸脱羧酶）是多胺生物合成中的限速酶，其活性受到特定抑制剂 AZs（抗氨基酸酶）的调控，而 AZs 又受到 AZI（抗氨基酸酶抑制剂）的抑制。ODC1 催化多胺生物合成的第一步和限速步骤，将鸟氨酸转化为腐胺，后者是多胺（如亚精胺和精胺）的前体。多胺对细胞增殖至关重要，并参与从 DNA 复制到细胞凋亡等多种细胞过程。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-T7;C-6*His

P11926 (M1-V461)

4953  [NCBI]

MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV

58 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, 8% Trehalose, 2% Mannitol, 4 mM TCEP, 0.05% Tween 80, pH 8.0.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.