2. 重组蛋白
  3. Cytokines and Growth Factors
  4. Interleukin & Receptors
  5. OSM Receptor
  6. OSMR beta 蛋白, Cynomolgus (HEK293, His)

OSMR beta 蛋白, Cynomolgus (HEK293, His)

目录号: HY-P700806
产品使用指南

OSMR β 蛋白是 2 型亚家族中的 I 型细胞因子受体，在细胞信号传导和免疫反应中至关重要。OSMR beta 作为制瘤素 M（一种在炎症、细胞生长和分化中发挥作用的细胞因子）的受体，对于下游信号传导和细胞功能调节至关重要。探索 OSMR beta 的功能和调节为开发治疗策略提供见解，以解决与细胞因子信号传导或免疫反应失调相关的疾病。OSMR beta 蛋白, Cynomolgus (HEK293, His) 是重组的 OSMR β 蛋白，由 HEK293 表达，带有 C-His 标签。OSMR beta 蛋白, Cynomolgus (HEK293, His) 全长 710 个氨基酸，分子量为 110-130 kDa。

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描述

OSMR beta Protein, a type I cytokine receptor in the type 2 subfamily, is pivotal in cellular signaling and immune responses. Serving as the receptor for oncostatin M, a cytokine with roles in inflammation, cell growth, and differentiation, OSMR beta is crucial for downstream signaling and cellular function regulation. Exploring OSMR beta's function and regulation offers insights for developing therapeutic strategies addressing diseases associated with cytokine signaling or immune response dysregulation. OSMR beta Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived OSMR beta protein, expressed by HEK293, with C-His labeled tag. The total length of OSMR beta Protein, Cynomolgus (HEK293, His) is 710 a.a., with molecular weight of 110-130 kDa.
研究背景

OSMR β 蛋白属于 I 型细胞因子受体家族，特别是 2 型亚家族。这种蛋白质在细胞信号传导和免疫反应中发挥着重要作用。它充当制瘤素 M 的受体，制瘤素 M 是一种参与炎症、细胞生长和分化等多种生物过程的细胞因子。OSMR β 蛋白对于下游信号通路的激活和细胞功能的调节至关重要。了解 OSMR β 蛋白的功能和调节可以为涉及细胞因子信号传导或免疫反应失调的疾病的治疗策略的开发提供有价值的见解。
种属

Cynomolgus
表达系统

HEK293
标签

C-His
蛋白编号

A0A2K5UFW5 (E28-S737)
基因 ID

102135082
蛋白结构
N-term
OSMR beta (E28-S737)
Accession # A0A2K5UFW5
His
C-term
同用名
IL-31R subunit beta; IL-31R-beta; IL-31RB; OSMR beta; OSMR; OSMRB; OSMRBMGC150626; PLCA1 ; IL-31R subunit β; IL-31R-β; OSMR β
分子量

110-130 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

OSMR beta Protein, Cynomolgus (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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