1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. OSM Receptor
  5. OSMR&GP130 蛋白, Human (HEK293, His-Flag)

OSMR&GP130 蛋白, Human (HEK293, His-Flag)

目录号: HY-P700807
产品使用指南

OSMR β 蛋白在免疫反应中至关重要,它通过与 IL12RB1 结合而与 IL-23R 形成白细胞介素 23 受体。它与 IL23 结合,通过 Jak-Stat 信号传导激活 T 细胞、NK 细胞和潜在的巨噬细胞/骨髓细胞。IL23 参与先天性和适应性免疫,有助于急性感染反应,并与自身免疫性疾病和肿瘤发生有关。在 IL12RB1 存在的情况下,OSMR beta 形成异二聚体 IL-23 受体,与 JAK2 相互作用并激活 STAT3。OSMR&GP130 蛋白, Human (HEK293, His-Flag) 是重组的蛋白二聚体复合物,包含 OSMR&GP130 蛋白,由 HEK293 表达,带有 C-His, C-Flag 标签。OSMR&GP130 蛋白, Human (HEK293, His-Flag),分子量为 100-140 kDa。

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描述

OSMR beta Protein, crucial in immune response, forms the interleukin-23 receptor with IL-23R by associating with IL12RB1. Binding IL23, it activates T-cells, NK cells, and potentially macrophage/myeloid cells through Jak-Stat signaling. Involved in innate and adaptive immunity, IL23 contributes to acute infection response and is implicated in autoimmune diseases and tumorigenesis. In the presence of IL12RB1, OSMR beta forms a heterodimeric IL-23 receptor, interacting with JAK2 and activating STAT3. OSMR&GP130 Protein, Human (HEK293, His-Flag) is a recombinant protein dimer complex containing human-derived OSMR&GP130 protein, expressed by HEK293, with C-His, C-Flag labeled tag. OSMR&GP130 Protein, Human (HEK293, His-Flag), has molecular weight of 100-140 kDa.

研究背景

IL-23R 蛋白通过与 IL12RB1 结合形成白细胞介素 23 受体,在免疫反应中发挥关键作用。该受体与 IL23 结合,并通过 Jak-Stat 信号级联触发 T 细胞、NK 细胞以及潜在的某些巨噬细胞/骨髓细胞的激活。IL23 参与先天性免疫和适应性免疫,并可能有助于外周组织对感染的急性反应。此外,IL23 与自身免疫性炎症性疾病有关,并已被证明在肿瘤发生中发挥重要作用。当 IL12RB1 存在时,IL-23R 形成异二聚体,充当 IL-23 受体并与 JAK2 相互作用以激活 STAT3

种属

Human

表达系统

HEK293

标签

C-His;C-Flag

蛋白编号

Q99650-1 (E28-M740)&P40189-1 (E23-E619)

基因 ID

9180&3572

分子量

100-140 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

OSMR&GP130 Protein, Human (HEK293, His-Flag) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
OSMR&GP130 Protein, Human (HEK293, His-Flag)
目录号:
HY-P700807
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