OSTM1 蛋白, Human (HEK293, His)

The OSTM1 protein is indispensable for the maturation and function of osteoclasts and melanocytes. It forms a heteromer with CLCN7, with CLCN7 as the α subunit and OSTM1 as the β subunit. OSTM1 Protein, Human (HEK293, His) is the recombinant human-derived OSTM1 protein, expressed by HEK293 , with C-His labeled tag. The total length of OSTM1 Protein, Human (HEK293, His) is 253 a.a., with molecular weight of 40-50 kDa.

OSTM1 蛋白对于破骨细胞和黑素细胞的成熟和功能至关重要。它与氯离子通道 7 (CLCN7) 形成异聚体，其中 CLCN7 代表 α 亚基，OSTM1 提供 β 亚基。这些异聚复合物共同促进氯离子通道的调节，并在与骨重塑和色素沉着相关的细胞过程中发挥关键作用。OSTM1 和 CLCN7 之间的相互作用强调了这些蛋白质在维持破骨细胞和黑素细胞的功能和成熟方面的合作性质。

Human

HEK293

C-His

Q86WC4 (A32-P284)

28962  [NCBI]

ALPFGSSPHRVFHDLLSEQQLLEVEDLSLSLLQGGGLGPLSLPPDLPDLDPECRELLLDFANSSAELTGCLVRSARPVRLCQTCYPLFQQVVSKMDNISRAAGNTSESQSCARSLLMADRMQIVVILSEFFNTTWQEANCANCLTNNSEELSNSTVYFLNLFNHTLTCFEHNLQGNAHSLLQTKNYSEVCKNCREAYKTLSSLYSEMQKMNELENKAEPGTHLCIDVEDAMNITRKLWSRTFNCSVPCSDTVP

Approximately 32-60 kDa due to the glycosylation

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.