OX40 Ligand/TNFSF4 蛋白, Human (HEK293)

OX40 Ligand/TNFSF4 Protein, a cytokine, binds specifically to TNFRSF4, acting as a potent T-cell co-stimulator for proliferation and cytokine production.Operating as a homotrimer, its engagement enhances immune response by activating and expanding T-cells.The interaction with TNFRSF4 contributes to intricate regulation, crucial for modulating T-cell functions and achieving effective and controlled immune activation.OX40 Ligand/TNFSF4 Protein, Human (HEK293) is the recombinant human-derived OX40 Ligand/TNFSF4 protein, expressed by HEK293 , with tag free.

OX40 配体/TNFSF4 蛋白是一种细胞因子，可特异性结合 TNFRSF4，并作为 T 细胞增殖和细胞因子产生的有效共刺激剂。作为同源三聚体，它与 TNFRSF4 结合，通过促进 T 细胞的激活和扩增来增强免疫反应。OX40 配体与其受体 TNFRSF4 之间的相互作用有助于 T 细胞介导的免疫反应的复杂调节，在调节 T 细胞功能以实现有效且受控的免疫激活方面发挥着至关重要的作用。

Measured by its ability to induce IL-8 secretion in HT1080 human fibrosarcoma cells transfected with human OX40/TNFRSF4. The ED₅₀ for this effect is 3.527 ng/mL, corresponding to a specific activity is 2.836×10⁵ U/mg.

• 
  Measured by its ability to induce IL-8 secretion in HT1080 human fibrosarcoma cells transfected with human OX40/TNFRSF4. The ED₅₀ for this effect is 3.527 ng/mL, corresponding to a specific activity is 2.836×10⁵ U/mg.

Human

HEK293

Tag Free

P23510-1 (Q51-L183)

7292

QVSHRYPRIQSIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEFCVL

Approximately 18-30 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.

<0.1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.