p67phox 蛋白, Human (sf9)

p67phox is central to activating NADPH oxidase, crucial for superoxide production. Forming a heterodimer with CYBA and CYBB, and interacting with NCF4 and NCF1, p67phox establishes vital connections within the complex. Its versatile associations include SYTL1, RAC1, NOXO1, S100A8, calprotectin (S100A8/9), and GBP7, highlighting its regulatory role. Enhanced interaction with CYBB in the presence of GBP7 underscores the dynamic nature of these protein-protein associations in orchestrating superoxide generation. p67phox Protein, Human (sf9) is the recombinant human-derived p67phox protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of p67phox Protein, Human (sf9) is 526 a.a., with molecular weight of ~60 kDa.

p67phox 蛋白在潜在 NADPH 氧化酶的激活中发挥着关键作用，这是超氧化物产生所必需的过程。作为 NADPH 氧化酶复合物的关键成分，它与膜蛋白 CYBA 和 CYBB 以及胞质亚基 NCF1、NCF2 和 NCF4 形成异二聚体。值得注意的是，p67phox 与 NCF4 和 NCF1 相互作用，通过其 C 端 SH3 结构域在复合物内建立关键连接。此外，它与 SYTL1 和 RAC1 结合，并可能与 NOXO1 相互作用，突出了其与监管元件相关的多功能性。与 S100A8、钙卫蛋白 (S100A8/9) 和 GBP7 的进一步相互作用强调了参与 NADPH 氧化酶活性调节的复杂网络。 GBP7 的存在增强了与 CYBB 的相互作用，强调了这些蛋白质-蛋白质关联在协调超氧化物生成中的动态性质。

Human

Sf9 insect cells

Tag Free

P19878 (N-G&P, M1-V526)

4688  [NCBI]

Approximately 60 kDa

Greater than 85% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.