PAX8 蛋白, Human (His)

PAX8 protein, a crucial transcription factor, is essential for thyroid-specific gene expression, maintaining the functional differentiation of thyroid cells. It plays a pivotal role in regulating the thyroid-specific gene profile, contributing to specialized thyroid cell function. PAX8 also interacts with WWTR1, indicating a potential partnership in modulating gene expression and cellular processes in thyroid cells. PAX8 Protein, Human (His) is the recombinant human-derived PAX8 protein, expressed by E. coli , with C-His labeled tag. The total length of PAX8 Protein, Human (His) is 145 a.a., with molecular weight of ~16 kDa.

PAX8 蛋白作为甲状腺细胞特有基因的甲状腺特异性表达所必需的转录因子，从而保持这些细胞的功能分化。PAX8 在调节甲状腺特异性基因表达谱中发挥着关键作用，有助于甲状腺细胞的特殊功能。此外，PAX8 与 WWTR1 相互作用，表明在调节甲状腺细胞类型内的基因表达和细胞过程方面存在潜在的伙伴关系。

Human

E. coli

C-His

Q06710 (P2-S146)

7849  [NCBI]

PHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDS

Approximately 17 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 10% glycerol or PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.