PD-1 蛋白, Cynomolgus (143a.a, HEK293, Fc)

PD-1 is a cell surface receptor on T and B cells that binds to PD-L1 and PD-L2. PD-1 is an immune checkpoint that protects autoimmunity by promoting apoptosis of antigen-specific T cells in lymph nodes (programmed cell death) and reducing apoptosis of regulatory T cells (anti-inflammatory, inhibitory T cells). The expression of PD-L1 on tumor cells inhibits anti-tumor activity through the binding of PD-1 to effector T cells. PD-1 Protein, Cynomolgus (143a.a, HEK293, Fc) is the recombinant cynomolgus-derived PD-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PD-1 Protein, Cynomolgus (143a.a, HEK293, Fc) is 143 a.a., with molecular weight of 60-75 kDa.

PD-1 是人体内由 PDCD1 基因编码的一种蛋白质。PD-1 是 T 细胞和 B 细胞上的一种细胞表面受体，通过抑制 T 细胞的炎症活性，下调免疫系统，促进自身耐受，从而调节免疫系统对人体细胞的应答。PD-1 是一个免疫检查点，通过促进淋巴结中抗原特异性 T 细胞的凋亡 (程序性细胞死亡) 和减少了调节性 T 细胞 (抗炎、抑制性T细胞) 的凋亡保护自身免疫。PD-1 可以结合两种配体，PD-L1 和 PD-L2。肿瘤细胞上 PD-L1 的表达通过 PD-1 与效应 T 细胞的结合抑制抗肿瘤活性。PD-1 基因敲除小鼠在 C57BL/6 和 BALB/c 基因背景下分别表现为狼疮样肾小球肾炎和扩张性心肌病。在小鼠胸腺中，当注射抗 CD3 抗体和大量胸腺细胞凋亡时，该基因在胸腺中被诱导表达。在 BALB/c 背景下繁殖的缺乏该基因的小鼠发展为扩张性心肌病并死于充血性心力衰竭。

Cynomolgus

HEK293

C-hFc

B0LAJ3 (L25-Q167)

102123659  [NCBI]

LESPDRPWNAPTFSPALLLVTEGDNATFTCSFSNASESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTRLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQ

60-75 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.