1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens Biotinylated Proteins
  3. Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Epithelial cell CD Proteins
  4. PD-L1
  5. PD-L1 蛋白, Mouse (Biotinylated, HEK293, His-Avi)

PD-L1 蛋白, Mouse (Biotinylated, HEK293, His-Avi)

目录号: HY-P703080
产品使用指南

PD-L1 蛋白作为抑制性受体 PDCD1/PD-1 的配体,对于维持免疫耐受至关重要。这种相互作用调节 T 细胞激活,限制效应反应,并可能刺激产生 IL10 的 T 细胞亚群。PD-L1 蛋白, Mouse (Biotinylated, HEK293, His-Avi) 是重组的 PD-L1 蛋白,由 HEK293 表达,带有 C-Avi, C-His 标签。

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SPR 检测服务   重组蛋白定制服务

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     可免费申领三个不同产品的试用装。

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描述

PD-L1 protein serves as a ligand for the inhibitory receptor PDCD1/PD-1 and is critical for maintaining immune tolerance. This interaction modulates T cell activation, limits effector responses and may stimulate IL10-producing T cell subsets. PD-L1 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived PD-L1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

研究背景

PD-L1 蛋白作为抑制性受体 PDCD1/PD-1 的配体,在维持自身免疫耐受方面发挥着至关重要的作用。这种相互作用调节 T 细胞的激活阈值,限制其效应反应,并可能刺激产生白细胞介素 10 (IL10) 的 T 细胞亚群。然而,肿瘤利用PDCD1介导的抑制途径来减弱抗肿瘤免疫力并逃避免疫系统的破坏,从而促进肿瘤存活。PD-L1 和 PDCD1/PD-1 之间的相互作用会抑制细胞毒性 T 淋巴细胞 (CTL) 的功能,但阻断该通路可以逆转耗尽的 T 细胞表型并使抗肿瘤反应正常化,为癌症免疫治疗提供了一种有前景的策略。

种属

Mouse

表达系统

HEK293

标签

C-His;C-Avi

蛋白编号

Q9EP73 (F19-T238)

基因 ID

60533

同用名
PD-L1; CD274; B7-H1; PDCD1L1; PDCD1LG1
分子量

39-54 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
PD-L1 Protein, Mouse (Biotinylated, HEK293, His-Avi)
目录号:
HY-P703080
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