2. 重组蛋白
  3. Enzymes & Regulators Biotinylated Proteins
  4. Transferases (EC 2)
  5. PDGF R beta 蛋白, Human (Biotinylated, sf9, His, Avi)

PDGF R beta 蛋白, Human (Biotinylated, sf9, His, Avi)

目录号: HY-P702756
产品使用指南

PDGF Rβ 蛋白是胚胎发育中不可或缺的一部分，并调节细胞增殖、存活、分化、趋化性、迁移和血管发育。它至关重要地将周细胞和平滑肌细胞招募到内皮，促进损伤部位的血管平滑肌细胞迁移和新内膜形成。PDGF R beta 蛋白, Human (Biotinylated, sf9, His, Avi) 是重组的 PDGF R beta 蛋白，由 Sf9 insect cells 表达，带有 Avi, His 标签。PDGF R beta 蛋白, Human (Biotinylated, sf9, His, Avi)

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描述

PDGF Rβ protein is integral in embryonic development and regulates cell proliferation, survival, differentiation, chemotaxis, migration, and vascular development. It crucially recruits pericytes and smooth muscle cells to the endothelium, promoting vascular smooth muscle cell migration and neointimal formation at the site of injury. PDGF R beta Protein, Human (Biotinylated, sf9, His, Avi) is the recombinant human-derived PDGF R beta, expressed by Sf9 insect cells , with Avi, His labeled tag. ,
研究背景

文中描述的受体是血小板源性生长因子受体α（PDGFRA）。PDGFRA参与多种细胞过程，包括胚胎发育、细胞增殖、存活、分化、趋化性、迁移和血管发育。它在周细胞和平滑肌细胞向内皮细胞的募集、血管平滑肌细胞的迁移和血管损伤部位新内膜的形成中发挥着至关重要的作用。PDGFRA 是心血管系统正常发育和肾小球毛细血管分支网络形成所必需的。它促进肌动蛋白细胞骨架的重排和膜褶皱的形成。其配体（包括同型二聚体 PDGFB、PDGFA 和 PDGFB 形成的异二聚体或同型二聚体 PDGFD）的结合会导致多个信号级联的激活。PDGFRA 磷酸化各种下游效应子，包括 PLCG1、PIK3R1、PTPN11、RASA1/GAP、CBL、SHC1、NCK1、PDCD6IP/ALIX 和 STAM。受体信号传导受到使受体及其下游效应子去磷酸化的蛋白磷酸酶以及激活受体的快速内化的调节。
种属

Human
表达系统

Sf9 insect cells
标签

Avi;His
蛋白编号

P09619-1 (Q557-L1106)
基因 ID

5159
同用名
PDGFRB; platelet-derived growth factor receptor, beta polypeptide; PDGFR; platelet-derived growth factor receptor beta; CD140b; JTK12; PDGFR1; PDGFR-beta; PDGF-R-beta; CD140 antigen-like family member B; platelet-derived growth factor receptor 1; beta-type platelet-derived growth factor receptor; CD140B; PDGFR-1
纯度

Greater than 80 % as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

PDGF R beta Protein, Human (Biotinylated, sf9, His, Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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