PDGF R beta 蛋白, Human (HEK293, His)

TRF1 protein is a telomere-binding protein that plays a crucial role in telomere maintenance and chromosome stability. It is involved in regulating telomere length and preventing DNA damage. PDGF R beta Protein, Human (HEK293, His) is the recombinant human-derived PDGF R beta protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PDGF R beta Protein, Human (HEK293, His) is 499 a.a., with molecular weight of 85-130 kDa.

PDGF R beta 蛋白编码细胞表面酪氨酸激酶受体，该受体与血小板衍生生长因子家族的成员相互作用，血小板衍生生长因子家族是间充质来源细胞的已知有丝分裂原。与受体单体结合的生长因子的特性决定了功能性受体是否形成同二聚体（与PDGFB或PDGFD）或异二聚体（与PDGFA和PDGFB）。该基因对于正常心血管系统发育和肌动蛋白细胞骨架的重排至关重要，该基因位于 5 号染色体上，两侧是粒细胞-巨噬细胞集落刺激因子和巨噬细胞集落刺激因子受体基因，所有三个基因都可能与 5-q 相关。综合症。5 号和 12 号染色体之间的易位导致该基因与 ETV6 基因融合，导致伴有嗜酸性粒细胞增多的慢性骨髓增殖性疾病。PDGF R beta 基因广泛表达，在胆囊 (RPKM 79.5)、胎盘 (RPKM 61.0) 和 21 个其他组织中表现出升高的水平，表明它参与多个器官的不同生理环境。

Measured by its binding ability in a functional ELISA. Immobilized PDGF-BB at 1 μg/mL (100 μL/well) can bind Biotinylated PDGF R beta. The ED₅₀ for this effect is 42.19 ng/mL.

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  Measured by its binding ability in a functional ELISA. Immobilized PDGF-BB at 1 μg/mL (100 μL/well) can bind Biotinylated PDGF R beta. The ED₅₀ for this effect is 42.19 ng/mL.

Human

HEK293

C-6*His

NP_002600.1 (L33-K531)

5159  [NCBI]

LVVTPPGPELVLNVSSTFVLTCSGSAPVVWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFVPDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFSGIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGNEVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPF

85-130 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.