PDZD11 蛋白, Human (His)

PDZD11 protein is a key mediator that promotes the docking of ADAM10 to adhesion zonules by interacting with PLEKHA7. PDZD11 is critical for subsequent binding to TSPAN33, which orchestrates complex protein-protein interactions at cellular junctions. PDZD11 Protein, Human (His) is the recombinant human-derived PDZD11 protein, expressed by E. coli , with N-His labeled tag.

PDZD11 蛋白是细胞相互作用中的关键介质，通过与 PLEKHA7 的相互作用促进 ADAM10 与粘附小带的对接。这种相互作用对于 PLEKHA7 随后与 ADAM10 结合蛋白 TSPAN33 的结合至关重要，突显了 PDZD11 在协调细胞连接处复杂的蛋白质-蛋白质相互作用中的作用。此外，PDZD11 表现出与 ATP2B1、ATP2B2、ATP2B3、ATP2B4 和 ATP7A 的相互作用，表明其参与钙和铜的转运过程。它与粘附小带处的 PLEKHA7 相互作用强调了它在细胞粘附和信号传导调节中的重要性。此外，PDZD11 与 SLC5A6 相互作用，表明可能参与钠依赖性转运过程的调节。复杂的相互作用网络表明 PDZD11 在协调多种细胞功能中发挥着至关重要的作用，需要进一步研究以揭示 PDZD11 在细胞信号传导和连接动力学中的精确分子机制和更广泛的影响。

Human

E. coli

N-His

Q5EBL8-1 (D2-H140)

51248  [NCBI]

DSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH

Approximately 18 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.