2. 重组蛋白
  3. CD Antigens Receptor Proteins
  4. Macrophage CD Proteins Stem Cell CD Proteins Platelet CD Proteins Erythrocyte CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  5. CD31/PECAM-1 Immunoglobulin-like Cell Adhesion Molecules
  6. CD31/PECAM-1 蛋白, Human (HEK293, Fc)

CD31/PECAM-1 蛋白, Human (HEK293, Fc)

目录号: HY-P70988
产品使用指南 技术支持

CD31/PECAM-1 是一种细胞-细胞粘附蛋白。CD31/PECAM-1 可调节内皮细胞中缓激素受体 BDKRB2 的激活和高渗休克诱导的 ERK1/2 活化以及诱导对动脉粥样硬化的易感性。CD31/PECAM-1 介导与内皮细胞的粘附，通过形成新的内皮细胞管调节肿瘤生长。CD31/PECAM-1 蛋白, Human (HEK293, Fc) 是重组的 CD31/PECAM-1 蛋白，由 HEK293 表达，带有 C-hFc 标签。

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描述

CD31/PECAM-1 is a cell-cell adhesion protein. CD31/PECAM-1 regulates the activation of the slow hormone receptor BDKRB2 in endothelial cells and the activation of ERK1/2 induced by hypertonic shock and induces susceptibility to atherosclerosis. CD31/PECAM-1 mediates adhesion to endothelial cells and regulates tumor growth by forming new endothelial cell tubes. CD31/PECAM-1 Protein, Human (HEK293, Fc) is the recombinant human-derived CD31/PECAM-1 protein, expressed by HEK293 , with C-hFc labeled tag.
研究背景

Platelet endothelial cell adhesion molecule (PECAM1) 也被称为 CD31 ，是一种细胞-细胞粘附蛋白。CD31/PECAM-1 通常存在于内皮细胞、血小板、巨噬细胞和库普弗细胞、粒细胞、淋巴细胞 (T 细胞、B 细胞和NK 细胞)、巨核细胞和破骨细胞中。CD31/PECAM-1 可调节缓激素受体 BDKRB2 激活、内皮细胞中缓激素和高渗休克诱导的 ERK1/2 活化以及诱导对动脉粥样硬化的易感性。CD31/PECAM-1 介导与内皮细胞的粘附，通过形成新的内皮细胞管调节肿瘤生长。
种属

Human
表达系统

HEK293
标签

C-hFc
蛋白编号

P16284-1 (Q28-K601)
基因 ID
蛋白结构
N-term
CD31 (Q28-K601)
Accession # P16284-1
hFc
C-term
同用名
Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA; PECA1; CD31; PECAM1
氨基酸序列

QENSFTINSVDMKSLPDWTVQNGKNLTLQCFADVSTTSHVKPQHQMLFYKDDVLFYNISSMKSTESYFIPEVRIYDSGTYKCTVIVNNKEKTTAEYQVLVEGVPSPRVTLDKKEAIQGGIVRVNCSVPEEKAPIHFTIEKLELNEKMVKLKREKNSRDQNFVILEFPVEEQDRVLSFRCQARIISGIHMQTSESTKSELVTVTESFSTPKFHISPTGMIMEGAQLHIKCTIQVTHLAQEFPEIIIQKDKAIVAHNRHGNKAVYSVMAMVEHSGNYTCKVESSRISKVSSIVVNITELFSKPELESSFTHLDQGERLNLSCSIPGAPPANFTIQKEDTIVSQTQDFTKIASKSDSGTYICTAGIDKVVKKSNTVQIVVCEMLSQPRISYDAQFEVIKGQTIEVRCESISGTLPISYQLLKTSKVLENSTKNSNDPAVFKDNPTEDVEYQCVADNCHSHAKMLSEVLRVKVIAPVDEVQISILSSKVVESGEDIVLQCAVNEGSGPITYKFYREKEGKPFYQMTSNATQAFWTKQKANKEQEGEYYCTAFNRANHASSVPRSKILTVRVILAPWKK

分子量

110-130 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CD31/PECAM-1 Protein, Human (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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