Pepsinogen C/PGC 蛋白, Rat (HEK293, His)

Pepsinogen C (PGC) functions as an enzyme with the ability to hydrolyze a diverse range of proteins. Pepsinogen C/PGC Protein, Rat (HEK293, His) is the recombinant rat-derived Pepsinogen C/PGC protein, expressed by HEK293 , with C-His labeled tag. The total length of Pepsinogen C/PGC Protein, Rat (HEK293, His) is 376 a.a., with molecular weight of ~42 kDa.

胃蛋白酶原 C (PGC) 是一种酶，是消化酶胃蛋白酶的前体。PGC 具有水解多种蛋白质的能力。这种酶主要由胃内壁的胃主细胞合成和分泌。一旦释放到胃的酸性环境中，PGC 就会裂解形成胃蛋白酶，胃蛋白酶是一种活性蛋白酶，负责将膳食蛋白质分解成更小的肽。胃的低 pH 值促进 PGC 转化为胃蛋白酶，从而触发该酶原的激活。PGC 在消化过程中的作用对于摄入蛋白质的初始分解至关重要，从而使其能够随后在胃肠道中消化和吸收。了解 PGC 的激活和功能有助于深入了解蛋白质消化和胃生理学的复杂机制。

Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK(Dnp)-OH. The specific activity is 41133.212 pmol/min/μg that incubate at room temperature for 10 minutes.

Rat

HEK293

C-6*His

P04073 (S17-V392)

24864  [NCBI]

SLLRVPLRKMKSIRETMKEQGVLKDFLKTHKYDPGQKYHFGNFGDYSVLYEPMAYMDASYFGEISIGTPPQNFLVLFDTGSSNLWVSSVYCQSEACTTHARFNPSKSSTYYTEGQTFSLQYGTGSLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPGLSSGGATTALQGMLGEGALSQPLFGVYLGSQQGSNGGQIVFGGVDKNLYTGEITWVPVTQELYWQITIDDFLIGDQASGWCSSQGCQGIVDTGTSLLVMPAQYLSELLQTIGAQEGEYGEYFVSCDSVSSLPTLSFVLNGVQFPLSPSSYIIQEDNFCMVGLESISLTSESGQPLWILGDVFLRSYYAIFDMGNNKVGLATSV

Approximately 42 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris, 150 mM NaCl, pH 7.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.