Periostin 蛋白, Human (781a.a, HEK293, His)

Periostin (POSTN) is a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. POSTN binds to integrins and BMP1 to support cell adhesion, cell migration and the structural integrity of connective tissues. Periostin Protein, Human (781a.a, HEK293, His) is the recombinant human-derived Periostin protein, expressed by HEK293 , with C-His labeled tag. The total length of Periostin Protein, Human (781a.a, HEK293, His) is 781 a.a., with molecular weight of 66-80 kDa.

骨膜蛋白 (POSTN) 是一种细胞外基质分泌蛋白，在包括心肌梗死后的组织发育和再生中起作用，包括伤口愈合和心室重构。POSTN 与整合素结合，支持上皮细胞的粘附和迁移，POSTN 还增强与 BMP1 在结缔组织纤维连接蛋白基质中的结合，以及随后赖氨酸氧化酶的蛋白水解激活，进而促进结缔组织的结构完整性。POSTN 在癌症干细胞的维持和转移中起作用。缺乏 POSTN 会导致心脏瓣膜疾病、骨骼和牙齿缺陷^[1][2]。

Measured by its ability to induce adhesion of ATDC5 mouse chondrogenic cells.When cells are added to POSTN-His coated plates (20 μg/mL, 100 μL/well), approximately >45% will adhere specifically after 30 minutes at 37°C.

Human

HEK293

C-His

B1ALD9 (M1-Q781)

10631  [NCBI]

66-80 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.