PEX19 蛋白, Human (GST)

PEX19 protein is pivotal in early peroxisomal biogenesis, acting as a cytosolic chaperone and import receptor for peroxisomal membrane proteins (PMPs). It binds to and stabilizes newly synthesized PMPs in the cytoplasm, particularly their hydrophobic domains. PEX19 targets PMPs to the peroxisome membrane by associating with integral membrane protein PEX3. Engaging in diverse interactions with peroxisomal membrane proteins and other components, PEX19 facilitates peroxisomal assembly. Additionally, it contributes to nuclear exclusion of CDKN2A, preventing TP53 degradation by MDM2 and interacting with tumor suppressor CDKN2A/p19ARF in intricate cellular processes. PEX19 Protein, Human (GST) is the recombinant human-derived PEX19 protein, expressed by E. coli, with N-GST labeled tag. The total length of PEX19 Protein, Human (GST) is 295 a.a., with molecular weight of 59.3 kDa.

PEX19 蛋白在早期过氧化物酶体生物合成中发挥着至关重要的作用，既作为胞质伴侣，又作为过氧化物酶体膜蛋白 (PMP) 的重要受体。其功能涉及结合并稳定细胞质中新合成的 PMP，特别是通过与其疏水性跨膜结构域的相互作用。随后，PEX19 通过与整合膜蛋白 PEX3 结合，将这些 PMP 靶向过氧化物酶体膜。值得注意的是，PEX19 参与多种蛋白质-蛋白质相互作用，与一系列过氧化物酶体膜蛋白形成复合物，例如 PEX10、PEX11A、PEX11B、PEX12、PEX13、PEX14 和 PEX16，以及其他关键成分，例如 PXMP2/PMP22、PXMP4 /PMP24、SLC25A17/PMP34、ABCD1/ALDP、ABCD2/ALDRP 和 ABCD3/PMP70。此外，PEX19 在 CDKN2A 的核排斥中发挥作用，防止其与 MDM2 相互作用，从而促进 TP53 的降解。此外，它与肿瘤抑制因子 CDKN2A/p19ARF 相互作用，突出了它参与复杂的细胞过程。

Human

E. coli

N-GST

P40855 (A2-C296)

5824  [NCBI]

AAAEEGCSVGAEADRELEELLESALDDFDKAKPSPAPPSTTTAPDASGPQKRSPGDTAKDALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDMTSQQEFTSCLKETLSGLAKNATDLQNSSMSEEELTKAMEGLGMDEGDGEGNILPIMQSIMQNLLSKDVLYPSLKEITEKYPEWLQSHRESLPPEQFEKYQEQHSVMCKICEQFEAETPTDSETTQKARFEMVLDLMQQLQDLGHPPKELAGEMPPGLNFDLDALNLSGPPGASGEQC

59.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.