PF-4/CXCL4 蛋白, Human (Biotinylated, His-Avi)

Wnt-10b protein is a signaling molecule that plays a key role in embryonic development and tissue homeostasis. It is involved in regulating cell proliferation, differentiation and migration. PF-4/CXCL4 Protein, Human (Biotinylated, His-Avi) is the recombinant human-derived PF-4/CXCL4 protein, expressed by E. coli , with C-Avi, N-His labeled tag. The total length of PF-4/CXCL4 Protein, Human (Biotinylated, His-Avi) is 70 a.a., with molecular weight of 13 kDa.

PF-4/CXCL4 蛋白是 CXC 趋化因子家族的成员，由该基因编码。这种趋化因子以同四聚体的形式从活化血小板的α颗粒中释放出来，对肝素具有高亲和力，在血小板聚集中发挥着至关重要的作用。除了参与血小板功能之外，PF-4/CXCL4 对各种细胞类型具有趋化性，并可作为造血、血管生成和 T 细胞功能的抑制剂。此外，它还具有针对恶性疟原虫的抗菌活性。该基因表现出偏向表达，在骨髓 (RPKM 14.3)、脾脏 (RPKM 2.7) 和一种其他组织中表达水平升高，强调了其在多个器官的各种生理环境中的潜在重要性。

Immobilized Human CCL5, His Tag at 5 μg/mL (100 μl/well) on the plate. Dose response curve for Biotinylated Human CXCL4, His Tag with the EC₅₀ of 1.1 μg/mL determined by ELISA.

Human

E. coli

N-His;N-Avi

NP_002610.1 (E32-S101)

5196  [NCBI]

13 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from 0.22 μm filtered solution in 4mM HCl, pH 3.0. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in 4 mM HCl (pH 3.0).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.