PICALM Recombinant 蛋白,Human(HEK293,C-His)

PICALM Human Recombinant Protein (HEK293, C-His) plays a critical role in recruiting clathrin and adapter protein complex 2 (AP2) to the cell membrane during coated pit formation and clathrin-vesicle assembly effect. It regulates the size of the clathrin cage and determines membrane recycling. PICALM Recombinant Protein,Human (HEK293,C-His) is the recombinant human-derived PICALM Recombinant protein,Human(HEK293,C-His), expressed by HEK293 , with C-10*His labeled tag. The total length of PICALM Recombinant Protein,Human (HEK293,C-His) is 652 a.a., with molecular weight of ~90-150 kDa.

PICALM 基因编码一种网格蛋白组装蛋白，对于在包被坑形成和网格蛋白-囊泡组装过程中将网格蛋白和衔接蛋白复合物 2 (AP2) 招募到细胞膜至关重要。它的作用可能延伸到调节网格蛋白笼的尺寸，从而确定要回收的膜的量。该蛋白参与 AP2 依赖性网格蛋白介导的内吞作用，特别是在神经肌肉接头处。值得注意的是，涉及该基因的染色体易位与各种血液恶性肿瘤有关。此外，该基因的多态性与阿尔茨海默病的风险有关。该基因表现出无处不在的表达，在脂肪、阑尾和 25 种其他组织中观察到显着水平。已鉴定出编码不同亚型的多个选择性剪接转录物变体。

Human

HEK293

C-10*His

Q13492/NP_009097 (M1-M652)

8301

MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQIQFM

Approximately 90-150 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 25 mM Tris-HCl, 10% glycerol, pH 7.3.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.