PIK3R3 蛋白, Human (Sf9, His, GST)

PIK3R3 protein, through its SH2 domain, interacts with phosphorylated protein-tyrosine kinases, crucially regulating their kinase activity. During insulin stimulation, PIK3R3 binds to IRS-1. Operating as a heterodimer with a p110 catalytic subunit, it interacts with AXL, expanding its functional network. PIK3R3 Protein, Human (Sf9, His, GST) is the recombinant human-derived PIK3R3 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of PIK3R3 Protein, Human (Sf9, His, GST) is 460 a.a., .

PIK3R3 蛋白通过其 SH2 结构域与激活的（磷酸化）蛋白酪氨酸激酶结合，在调节其激酶活性中发挥关键作用。此外，在胰岛素刺激过程中，PIK3R3 与 IRS-1 形成结合。该蛋白以异二聚体的形式发挥作用，包含调节亚基 (PIK3R3) 和 p110 催化亚基（PIK3CA、PIK3CB 或 PIK3CD）。此外，PIK3R3 展示了与 AXL 的相互作用，为其功能网络做出了贡献。

Human

Sf9 insect cells

N-8*His;N-GST

Q92569 (Y2-R461)

8503

82.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5% glycerol, 1 mM DTT, 0.1 M Trehalose.

<1 EU/μg, determined by LAL method.

Please use rapid thawing with running water to thaw the protein.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.