PLGF 蛋白, Rhesus macaque (HEK293, His)

PLGF protein is an important growth factor in angiogenesis and endothelial cell growth, stimulating cell proliferation and migration by binding to the FLT1/VEGFR-1 receptor. PLGF plays a crucial role in angiogenesis and also contributes to tumor growth, highlighting its involvement in pathological angiogenesis. PLGF Protein, Rhesus macaque (HEK293, His) is the recombinant Rhesus Macaque-derived PLGF protein, expressed by HEK293 , with C-His, C-6*His labeled tag. The total length of PLGF Protein, Rhesus macaque (HEK293, His) is 152 a.a., with molecular weight of ~28-32 kDa.

PLGF 蛋白是血管生成和内皮细胞生长不可或缺的生长因子，对这些细胞的增殖和迁移具有刺激作用。PLGF 通过与 FLT1/VEGFR-1 受体结合发挥作用，在协调血管生成过程中发挥着至关重要的作用。此外，它还有助于肿瘤生长，强调其参与病理性血管生成。在结构上，PLGF 作为反向平行同二聚体存在，通过二硫键连接。此外，它可以与 VEGFA/VEGF 形成异二聚体，表明在调节血管生长和功能中发挥动态作用。PLGF 的多方面作用和结构排列强调了其在调节血管过程和肿瘤发展中的重要性。

Measured in a cell proliferation assay using MDA-MB-231 Human Breast Cancer Cells. The ED50 for this effect is 1.493 μg/mL, corresponding to a specific activity is 669.792 units/mg.

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  Measured in a cell proliferation assay using MDA-MB-231 Human Breast Cancer Cells. The ED₅₀ this effect is 1.493 μg/mL, corresponding to a specific activity is 669.792 units/mg.

Rhesus Macaque

HEK293

C-His;C-6*His

F7HB10-1 (L19-R170)

701219  [NCBI]

LPAVPPQQWALSPGNGSSEVEVVPFQEVWGRSYCRALERLVDIVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETVNVTMQLLKIRSGDRPSYVELTFSQHVRCECRPLREKMKPERRRPKGRGKRRREKQRPTDCHLCGDAVPRR

Approximately 28-32 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.