PNPLA2 蛋白, Human (His-SUMO)

The PNPLA2 protein catalyzes the hydrolysis of triglycerides, preferably long-chain fatty acid esters, in lipid droplets. PNPLA2 Protein, Human (His-SUMO) is the recombinant human-derived PNPLA2 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

PNPLA2 蛋白是脂质代谢的关键参与者，是脂肪细胞和非脂肪细胞脂滴内甘油三酯水解第一步的催化剂。PNPLA2 对甘油主链 sn-2 位点的长链脂肪酸酯的水解表现出明显的偏好，在脂肪分解级联中与 LIPE/HLS 和 DGAT2 协同作用。除了其主要功能外，PNPLA2 还表现出其他活性，包括酰基甘油转酰基酶和磷脂酶 A2 功能，证明了其在脂质相关过程中的多功能性。此外，它还具有调节脂肪体大小的作用，并参与脂肪体降解。此外，PNPLA2 有助于能量稳态，并可能增强甘油三酯在饥饿时的水解，从而在能量消耗条件下提供游离脂肪酸进行氧化。此外，PNPLA2催化酯键的形成，在脂肪细胞中生成羟基脂肪酸的脂肪酸酯（FAHFAs）（FAHFAs是一类可以治疗2型糖尿病的内源性脂质），从而扩大其在脂质稳态中的作用。多方位参与。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-SUMO;N-6*His

Q96AD5-1 (M1-L504)

57104  [NCBI]

MFPREKTWNISFAGCGFLGVYYVGVASCLREHAPFLVANATHIYGASAGALTATALVTGVCLGEAGAKFIEVSKEARKRFLGPLHPSFNLVKIIRSFLLKVLPADSHEHASGRLGISLTRVSDGENVIISHFNSKDELIQANVCSGFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKNTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPLVLREMCKQGYRDGLRFLQRNGLLNRPNPLLALPPARPHGPEDKDQAVESAQAEDYSQLPGEDHILEHLPARLNEALLEACVEPTDLLTTLSNMLPVRLATAMMVPYTLPLESALSFTIRLLEWLPDVPEDIRWMKEQTGSICQYLVMRAKRKLGRHLPSRLPEQVELRRVQSLPSVPLSCAAYREALPGWMRNNLSLGDALAKWEECQRQLLLGLFCTNVAFPPEALRMRAPADPAPAPADPASPQHQLAGPAPLLSTPAPEARPVIGALGL

Approximately 71.3 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.