PRNP/CD230 蛋白, Mouse (HEK293, Fc)

The PRNP/CD230 protein is involved in multiple cellular processes and may affect neuronal development, synaptic plasticity, and myelin maintenance.It promotes myelin homeostasis, induces apoptosis, and interacts with other proteins.PRNP/CD230 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PRNP/CD230 protein, expressed by HEK293 , with C-hFc labeled tag.

PRNP/CD230 蛋白虽然其主要生理功能尚不清楚，但与多种细胞过程有关，表明其在神经元发育、突触可塑性和神经元髓鞘维护中具有潜在作用。它可能通过充当 ADGRG6 受体的激动剂并参与铁的摄取和稳态来促进髓磷脂稳态。PRNP 的可溶性低聚物已被证明对培养的神经母细胞瘤细胞具有毒性，可在体外诱导细胞凋亡。与 GPC1 的结合（由其硫酸乙酰肝素链介导）将 PRNP 引导至脂筏，并为抗坏血酸介导的 GPC1 脱氨酶降解其硫酸乙酰肝素侧链提供 Cu(2+) 或 Zn(2+)。该蛋白质表现出单体状态，并且可以形成同二聚体，表现出聚集成以交叉β脊柱为特征的淀粉样原纤维的倾向。铜结合可能促进 PRNP 的寡聚化。与 GRB2、APP、ERI3/PRNPIP、SYN1 和 ADGRG6 的相互作用凸显了其参与多种细胞过程，而错误定位的胞质暴露的 PrP 与 MGRN1 结合，改变 MGRN1 亚细胞位置并导致溶酶体增大。与 KIAA1191 和 APP 的其他相互作用进一步强调了 PRNP 在细胞功能中的多功能性。

Mouse

HEK293

C-hFc

P04925 (K23-S230)

19122  [NCBI]

60-68 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.