Prolactin R 蛋白, Human (HEK293, His)

The prolactin R protein is the receptor for prolactin, encoded by this gene, and promotes prolactin-dependent signaling through ligand-induced dimerization. This gene exhibits multiple splice variants, encodes multiple isoforms, and has a potential role in regulating the endocrine and autocrine effects of prolactin. Prolactin R Protein, Human (HEK293, His) is the recombinant human-derived Prolactin R protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Prolactin R Protein, Human (HEK293, His) is 210 a.a..

由该基因编码的催乳素 R 蛋白是垂体前叶激素催乳素的受体，并且是 I 型细胞因子受体家族的成员。其功能涉及催乳素依赖性信号传导，由配体诱导的催乳素受体二聚化触发。该基因表现出几种编码不同膜结合和可溶亚型的选择性剪接转录物变体，可能有助于调节正常组织和癌症中催乳素的内分泌和自分泌作用。催乳素 R 的表达存在偏差，在胎盘 (RPKM 18.9)、子宫内膜 (RPKM 11.6) 和其他八个组织中观察到显着水平，强调了其在各种生理环境中的特殊作用及其在生殖和内分泌过程中的潜在参与。

Measured by its ability to inhibit Prolactin-induced proliferation of Nb2-11 rat lymphoma cells. The ED₅₀ this effect is 0.03362-0.095 μg/mL in the presence of 0.5 ng/mL of recombinant human Prolactin.

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  Measured by its ability to inhibit Prolactin-induced proliferation of Nb2‑11 rat lymphoma cells. The ED₅₀ this effect is 0.03362 μg/mL in the presence of 0.5 ng/mL of recombinant human Prolactin, corresponding to a specific activity is 2.97×10⁴ units/mg.

Human

HEK293

C-10*His

NP_000940.1 (Q25-D234)

5618  [NCBI]

QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMND

Approximately 32-38 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, 5-8% Trehalose, 0.01% Tween 80, pH 7.4 or PBS, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.