PSAP/Prosaposin 蛋白, Rat (HEK293, His)

PSAP (or Prosaposin) has multiple functions, including ganglioside binding, protein homodimerization, and scaffolding protein binding.It is involved in processes such as GM1 transport, β-galactosidase regulation, and prostate development.PSAP/Prosaposin Protein, Rat (HEK293, His) is the recombinant rat-derived PSAP/Prosaposin protein, expressed by HEK293 , with C-His labeled tag.

PSAP（或 Prosaposin）预计具有多种功能，包括神经节苷脂结合活性、蛋白质同二聚化活性和支架蛋白结合活性。预计它会参与神经节苷脂 GM1 转运至膜、β-半乳糖苷酶活性的正向调节和前列腺发育等过程。预计它会在对基因表达产生负面影响的过程上游或内部发挥作用，预计还会参与动物器官发育、糖基神经酰胺代谢过程和蛋白质运输。预计 PSAP 位于聚集体、细胞外区域和晚期内体，在细胞外空间和溶酶体中具有活性。该基因的人类直系同源物与由于 saposin C 缺乏而导致的非典型戈谢病、复合性 saposin 缺乏和迟发性帕金森病等疾病有关。PSAP 在脾脏、大脑和其他九种组织等组织中表现出偏向表达，表明其参与多种生理过程。

Rat

HEK293

C-His

NP_037145.2 (S17-N554)

25524  [NCBI]

SPVQDPKICSGGSAVVCRDVKTAVDCRAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQRQLESNKIPEVDLARVVAPFMSNIPLLLYPQDRPRSQPQPKANEDVCQDCMKLVTDIQTAVRTNSSFVQGLVDHVKEDCDRLGPGVSDICKNYVDQYSEVAVQMMMHMQPKEICVMVGFCDEVKRVPMRTLVPATEAIKNILPALELTDPYEQDVIQAQNVIFCQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQKNGGFCEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLLEILVEVMDPSFVCSKIGVCPSAYKLLLGTEKCVWGPGYWCQNMETAARCNAVDHCKRHVWN

Approximately 55-75 kDa.

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.