PVR/CD155 蛋白, Human (HEK293, His)

PVR/CD155 Protein, Human (HEK293, His) is a recombinant Human PVR expressed in HEK 293 cells with a His tag at the N-terminus. PVR, Human plays a role in cancer cell invasion and migration^[1][2].

PVR/CD155，也称为人脊髓灰质炎病毒受体 (PVR)，是免疫球蛋白 (Ig) 样分子亚家族的成员，由 N 端可变结构域、随后的两个恒定结构域、单个跨膜结构域组成区和可变长度的细胞质尾。CD155 结合细胞外基质蛋白玻连蛋白，从而介导细胞与基质的接触。CD155 的胞质尾部与网格蛋白接头复合物的 μ1B 亚基相互作用，导致 CD155 在极化上皮细胞中定向转运^[1][2]。

Immobilized Human TIGIT-Fc at 5μg/mL (100 μL/well) can bind PVR/CD155 Protein, Human (HEK 293, His) and the ED₅₀ is 10-30 ug/mL.

Human

HEK293

C-6*His

NP_006496 (W21-N343)

5817  [NCBI]

WPPPGTGDVVVQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGESGSMAVFHQTQGPSYSESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTMGPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKEGPPSEHSGMSRN

Approximately 58.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. Mandai K, et, al. Nectins and nectin-like molecules in development and disease. Curr Top Dev Biol. 2015;112:197-231.  [Content Brief]

  [2]. Ravens I, et, al. Characterization and identification of Tage4 as the murine orthologue of human poliovirus receptor/CD155. Biochem Biophys Res Commun. 2003 Dec 26;312(4):1364-71.  [Content Brief]